CosmeticsUnregulated/Therapeutic
SNAP-8
Synonyms: Acetyl Octapeptide-3
Sequence: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
History & Discovery Timeline
SNAP-8 was developed by Lipotec as a structural elongation and optimization of Argireline, extending it to an octapeptide sequence.
What it is: It is a synthetic octapeptide (Acetyl Octapeptide-3) designed as a topical anti-wrinkle agent. It falls under Anti-aging/Cosmetic.
Proposed Mechanisms & Research Findings: Like Argireline, it blocks the SNARE complex formation to prevent muscle contractions, displaying higher potency in topical studies.
Regulatory & Safety Status: It is not FDA approved as a drug, but is permitted in cosmetics. Unlicensed injectable formulations are hazardous.
Athletic & Anti-Doping Status: It is not prohibited by WADA.
Understanding SNAP-8 Key Facts
Primary Target System:CNS
Residue Count / Length:10 Amino Acids
Primary Action & Category:SNARE Complex Inhibitor (Cosmetics)
Primary Receptors:SNARE vesicle docking site
Figure 1: Detailed molecular mechanism pathways of SNAP-8 (click to enlarge).