Growth Hormone SecretagoguesWADA Prohibited
PEG-MGF
Synonyms: Pegylated Mechano-Growth Factor, IGF-1Ec pegylated
Sequence: Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-His-Lys-NH2 conjugated to Polyethylene Glycol
Critical Safety & Regulatory Notice
PEG-MGF is classified as a regulated, unapproved, or research-only substance. Doping/Regulatory Status: Not FDA approved. Strictly prohibited by WADA under Section S2.. Clinical safety profiles for human use are deficient or not approved.
History & Discovery Timeline
PEG-MGF was identified by Goldspink and colleagues in the early 2000s as a splice variant of IGF-1 (IGF-1Ec) induced by mechanical overload. Pegylation was added to prevent rapid degradation.
What it is: It is pegylated Mechano Growth Factor, a splice variant of IGF-1. It falls under the Metabolic category.
Proposed Mechanisms & Research Findings: It stimulates local muscle stem cell (satellite cell) activation and proliferation, promoting muscle repair and hypertrophy without relying on systemic growth hormone.
Regulatory & Safety Status: It is not FDA approved. Online gray-market sourcing presents significant health risks, including immune reactions to the PEG group and unsterile preparations.
Athletic & Anti-Doping Status: Strictly prohibited by WADA under Section S2 as an insulin-like growth factor analog.
Understanding PEG-MGF Key Facts
Primary Target System:NEUROENDOCRINE
Residue Count / Length:25 Amino Acids
Primary Action & Category:Muscle Stem Cell Activator (Growth Hormone Secretagogues)
Primary Receptors:MGF Specific Binding Sites
Figure 1: Detailed molecular mechanism pathways of PEG-MGF (click to enlarge).