Systemic HormonesUnregulated/Therapeutic
DSIP
Synonyms: Delta Sleep-Inducing Peptide
Sequence: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
History & Discovery Timeline
DSIP (Delta Sleep-Inducing Peptide) was isolated from cerebral venous blood of sleeping rabbits in 1977 by Schoenenberger and Monnier, who observed its ability to induce slow-wave sleep.
What it is: It is a synthetic 9-amino-acid peptide categorized under Tissue Repair/Immune (neurobiology).
Proposed Mechanisms & Research Findings: It modulates neuromodulatory activity, interacting with GABAergic, glutamatergic, and opioid systems to induce delta-wave sleep and reduce stress.
Regulatory & Safety Status: It is not FDA approved. It remains an investigational peptide. Sourcing from online vendors poses serious purity and safety concerns.
Athletic & Anti-Doping Status: It is not prohibited by WADA, although athletes should monitor sedative use rules.
Understanding DSIP Key Facts
Primary Target System:CNS
Residue Count / Length:9 Amino Acids
Primary Action & Category:Sleep Regulatory Peptide (Systemic Hormones)
Primary Receptors:DSIP Specific Binding Sites

Figure 1: Detailed molecular mechanism pathways of DSIP (click to enlarge).