Systemic HormonesWADA Prohibited
Alarelin
Synonyms: Alarelin Acetate, GnRH Agonist, Gonadotropin-Releasing Hormone Analog
Sequence: Pyr-His-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-NHEt
Critical Safety & Regulatory Notice
Alarelin is classified as a regulated, unapproved, or research-only substance. Doping/Regulatory Status: Approved for veterinary use and clinical human use in several nations. Prohibited by WADA under Section S2.. Clinical safety profiles for human use are deficient or not approved.
History & Discovery Timeline
Alarelin was synthesized in the early 1980s by Syntex researchers as a highly active GnRH nonapeptide agonist.
What it is: It is a synthetic nonapeptide analog of Gonadotropin-Releasing Hormone (GnRH). It falls under the Metabolic category.
Proposed Mechanisms & Research Findings: It acts as a GnRH receptor agonist, initially stimulating and subsequently downregulating gonadotropin release, used to manage ovulation and hormone-dependent disorders.
Regulatory & Safety Status: It is not FDA approved in the US but is used in veterinary medicine and clinical research. Online sourcing carries serious risks of hormonal dysfunction.
Athletic & Anti-Doping Status: Strictly prohibited by WADA under Section S2 as a gonadotropin agonist.
Understanding Alarelin Key Facts
Primary Target System:NEUROENDOCRINE
Residue Count / Length:11 Amino Acids
Primary Action & Category:GnRH Receptor Agonist (Systemic Hormones)
Primary Receptors:GnRH Receptor (GnRHR)
Figure 1: Detailed molecular mechanism pathways of Alarelin (click to enlarge).